Clinical and electrocardiography changes in patients treated with capecitabine.
Chemotherapy
; 57(5): 381-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21997165
ABSTRACT
BACKGROUND:
We aimed to identify the incidence of cardiac events with capecitabine treatment.METHODS:
The study included 52 patients (median age 59 years) with cancer treated at our Medical Oncology Clinic between 2009 and 2010. Cardiac events from capecitabine treatment were classified into 4 groups cardiac symptoms, physical signs, electrocardiography (ECG) findings, and severe adverse cardiac effects.RESULTS:
The patients received either single-agent capecitabine or a combination chemotherapy including capecitabine. After initiation of capecitabine, 18 patients (34.6%) had new onset cardiovascular symptoms, 6 (11.5%) had new onset physical signs and 17 (32.6%) had new onset ECG findings. New onset ECG findings included prolonged corrected QT interval (n = 10, 19.2%) and prolonged PR interval (n = 3, 5.8%). Severe adverse capecitabine-induced cardiac side effects were observed in 5.8% of the patients, but none of the patients had myocardial infarction or died.CONCLUSION:
Cardiac events are not rare during capecitebine treatment and patients should be followed closely to avoid cardiac morbidity and mortality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Desoxicitidina
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Eletrocardiografia
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Fluoruracila
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article