Alterations in tyrosine aminotransferase isoenzymes of liver of rats as a function of age.
Mech Ageing Dev
; 6(6): 431-9, 1977.
Article
em En
| MEDLINE
| ID: mdl-21998
ABSTRACT
The specific activities (units/mg protein) of tyrosine aminotransferase (TAT) and its isoenzymes, cytoplasmic (c-), mitochondrial (m-) and nuclear (n-TAT), of the liver of 6-, 35- and 76-week old male albino rats were determined. The activities of all the isoenzymes are highest at 6 weeks and are significantly lower at 35 weeks. Total TAT and c-TAT remain unchanged, m-TAT decreases and n-TAT increases significantly after 35 weeks. c-TAT was partially purified from the liver of rats of the three ages to study its kinetic and molecular properties. These properties apparently do not change as a function of age.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina Transaminase
/
Isoenzimas
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article