Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.
Antimicrob Agents Chemother
; 56(1): 552-4, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22005995
ABSTRACT
We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with (213)Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while (188)Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioimunoterapia
/
Imunoconjugados
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Criptococose
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Cryptococcus neoformans
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Pulmão
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Anticorpos Antifúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article