Ultrastructural aspects of aging rat hippocampus after long-term administration of acetyl-L-carnitine.
Int J Clin Pharmacol Res
; 10(1-2): 59-63, 1990.
Article
em En
| MEDLINE
| ID: mdl-2201657
ABSTRACT
In aged rats a decrease in axosomatic synapses of granule cells as well as a decrease in the number of synaptic vesicles of giant synapses was found. These phenomena were supposed to be correlated on the basis of a feed-back circuit existing at the level of the dentate gyrus. In fact the axosomatic synapses of the granules are inhibitory gamma-aminobutyric acid-ergic terminals of interneurons. Interneurons receive excitatory afferences from granules via the giant synapses of the mossy fibre collaterals. This results in a feed-back regulation of granule cell activity. The long-term administration of acetyl-L-carnitine to aged rats restores a synaptic pattern comparable to that of young rats. This effect on synaptic plasticity is transient.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcarnitina
/
Carnitina
/
Hipocampo
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article