Triterpenoid saponins from Hydrocotyle bonariensis Lam.
Phytochemistry
; 73(1): 142-7, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22019087
ABSTRACT
Phytochemical investigation of the under-ground parts of Hydrocotyle bonariensis led to the isolation of five oleanane-type triterpenoid saponins, 3-O-{ß-D-glucopyranosyl-(1 â 2)-[α-L-arabinopyranosyl-(1 â 3)]-ß-D-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-22-O-acetyl-R(1)-barrigenol, 3-O-{ß-D-glucopyranosyl-(1 â 2)-[α-L-arabinopyranosyl-(1 â 3)]-ß-D-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-28-O-acetyl-R(1)-barrigenol, 3-O-{ß-D-glucopyranosyl-(1 â 2)-[α-L-arabinopyranosyl-(1 â 3)]-ß-D-glucuronopyranosyl}-21-O-acetyl-R(1)-barrigenol, 3-O-{ß-D-glucopyranosyl-(1 â 2)-[α-L-arabinopyranosyl-(1 â 3)]-ß-D-glucuronopyranosyl}-R(1)-barrigenol, and 3-O-{ß-D-glucopyranosyl-(1 â 2)-[α-L-arabinopyranosyl-(1 â 3)]-ß-D-glucuronopyranosyl}-22-O-(2-methylbutyroyl)-A(1)-barrigenol, together with the known saniculoside-R1. Their structures were established by 2D NMR techniques and mass spectrometry. Six compounds were evaluated against two human colon cancer cell lines, HCT 116 and HT-29. Two compounds showed weak cytotoxicity with IC(50) 24.1 and 24.0, 83.0 and 83.6 µM against HT-29 and HCT 116, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
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Apiaceae
/
Antineoplásicos Fitogênicos
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article