Polypeptide grafted hyaluronan: A self-assembling comb-branched polymer constructed from biological components.
Eur Polym J
; 47(10): 2022-2027, 2011 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-22021933
ABSTRACT
Rheological evidence is provided demonstrating that covalent grafting of monodisperse isotactic poly(L-leucine) branches onto linear hyaluronan (HA) polysaccharide chains yields comb-branched HA chains that self-assemble into long-lived physical networks in aqueous solutions driven by hydrophobic interactions between poly(L-leucine) chains. This is in stark contrast to native (unmodified) HA solutions which exhibit no tendency to form long-lived physical networks.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article