Synthesis of the thiazole-thiazoline fragment of largazole analogues.
J Org Chem
; 76(23): 9845-51, 2011 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-22032297
ABSTRACT
The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Depsipeptídeos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article