C3-triiodocyclotriveratrylene as a key intermediate to fluorescent probes: application to selective choline recognition.
Org Biomol Chem
; 9(24): 8489-94, 2011 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-22038183
ABSTRACT
A new strategy to obtain fluorescent cyclotriveratrylene (CTV) probes is proposed. The key intermediate, a triiodo CTV, is prepared in 3 steps with 47% overall yield. The whole synthesis requires only one purification step. The potential of this triiodo CTV as an intermediate is illustrated through the synthesis of a fluorescent phosphorylated probe that is able to bind choline and acetylcholine in pseudo-physiological conditions, with selectivity towards choline. As a consequence, this intermediate should allow us to rapidly form a library of probes in order to highlight the most promising ones.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Colina
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article