Impact of host proteases on reovirus infection in the respiratory tract.
J Virol
; 86(2): 1238-43, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22072772
ABSTRACT
Virion uncoating is an essential early event in reovirus infection. In natural enteric infections, rapid proteolytic uncoating of virions is mediated by pancreatic serine proteases. The proteases that promote reovirus disassembly and cell entry in the respiratory tract remain unknown. In this report, we show that endogenous respiratory and inflammatory proteases can promote reovirus infection in vitro and that preexisting inflammation augments in vivo infection in the murine respiratory tract.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Infecções por Reoviridae
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Orthoreovirus de Mamíferos
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Interações Hospedeiro-Patógeno
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Serina Proteases
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article