[DNA sequence-specific ligands: XIV. Synthesis of fluorescent biologicaly active dimeric bisbenzimidazoles-DB(3, 4, 5, 7, 11)].
Bioorg Khim
; 37(4): 530-41, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-22096996
ABSTRACT
Five fluorescent symmetric dimeric bisbenzimidazoles DB(n) have been synthesized containing four 2,6-substited benzimidazole fragments and differ in length of oligomethylene linker (n=3, 4, 5, 7, 11) between the two bisbenzimidazole blocks. The ability of these dimeric bisbenzimidazoles to form complexes with double-stranded DNA (dsDNA) was shown by spectral methods. Upon binding to dsDNA DB(n) are localized in the minor groove. The DNA-methyltransferase Dnmt3a inhibition data are demonstrate the site-specific binding of dimeric bisbenzimidazoles DB(3) and DB(11) with oligonucleotide duplex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Pareamento de Bases
/
Corantes Fluorescentes
/
Bisbenzimidazol
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Ru
Ano de publicação:
2011
Tipo de documento:
Article