Occidiofungin's chemical stability and in vitro potency against Candida species.
Antimicrob Agents Chemother
; 56(2): 765-9, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22106210
ABSTRACT
Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.0 µg/ml. Occidiofungin retains its in vitro potency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 µg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin against Candida albicans were performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida
/
Lipopeptídeos
/
Antifúngicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article