Albendazole versus metronidazole in the treatment of adult giardiasis: a randomized, double-blind, clinical trial.
Curr Med Res Opin
; 28(1): 149-54, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22114904
ABSTRACT
BACKGROUND:
Albendazole (ABZ) is a benzimidazole carbamate compound currently in use for human medical practice against enterobiasis and soil-transmitted helminthiasis (STH); However, its spectrum of activity is broad and goes beyond these infections.OBJECTIVE:
This study compares the efficacy and safety of ABZ versus metronidazole (MTZ) in human giardiasis. RESEARCH DESIGN ANDMETHODS:
A randomized, double-blind, clinical trial was carried out at the Centre of Hygiene, Epidemiology and Microbiology in Matanzas City, Cuba. Adult patients with confirmed symptomatic G. duodenalis mono-infection were randomly assigned to receive either ABZ [400 mg daily (n = 75)] or MTZ [250 mg t.i.d. (n = 75)], both for 5 days. Follow-up fecal samples were obtained at 3, 5, 7 days after treatment end.RESULTS:
The efficacy was similar for both treatment groups ABZ (82.6%) and MTZ (85.3%); p > 0.05. Side-effects including bitter taste, headache, vomiting and dizziness were significantly higher in the MTZ group. Abdominal pain was significantly higher in ABZ group.CONCLUSION:
ABZ was found as effective as MTZ in the treatment of G. duodenalis infections in adult patients from Cuba and could be a useful drug in areas where co-infection with STH infections is common.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Albendazol
/
Giardíase
/
Metronidazol
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
País/Região como assunto:
Caribe
/
Cuba
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article