Generating mature ß-cells from embryonic stem cells: strategies for late-stage differentiation.
Vitam Horm
; 87: 79-92, 2011.
Article
em En
| MEDLINE
| ID: mdl-22127238
ABSTRACT
Generation of mature pancreatic ß-cells from embryonic stem (ES) cells in vitro could provide a therapy for insulin-dependent diabetes mellitus. Recent ES cell differentiation protocols have improved the differentiation efficiency toward ß-cells by recapitulating in vivo pancreatic development. Toward this end, there is a large number of developmental and ß-cell functional studies that could guide the design of more efficient differentiation protocols, predominantly during the late stages. In this review, I have classified these studies according to the intracellular signaling pathways they relate to--phosphatidylinositol 3-kinase, Hedgehog, Calcineurin/NFAT, Epac, and bone morphogenetic protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Células Secretoras de Insulina
/
Células-Tronco Embrionárias
Tipo de estudo:
Guideline
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article