Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A-C: Fibronectin Expression Regulators from Aspergillus novofumigatus.
Sci Pharm
; 79(4): 937-50, 2011.
Article
em En
| MEDLINE
| ID: mdl-22145116
ABSTRACT
Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article