The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.
J Virol
; 86(4): 2176-87, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22156529
ABSTRACT
The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Iniciação Traducional da Cadeia Peptídica
/
RNA Viral
/
Orthohantavírus
/
Proteínas não Estruturais Virais
/
Infecções por Hantavirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article