Tissue transglutaminase: a novel therapeutic target in cerebral amyloid angiopathy.
Neurodegener Dis
; 10(1-4): 317-9, 2012.
Article
em En
| MEDLINE
| ID: mdl-22156619
ABSTRACT
Accumulation of amyloid-ß (Aß) in brain vessel walls, known as cerebral amyloid angiopathy (CAA), plays a key role in Alzheimer's disease pathogenesis. CAA might result from impaired transport of Aß out of the brain. Although the mechanisms underlying reduced Aß transport are largely unknown, thickening of basement membrane extracellular matrix (ECM) is likely involved. Tissue transglutaminase (tTG) is an enzyme capable of modulating the ECM by covalently cross-linking ECM proteins. Recently, our group found that tTG and its cross-linking activity are associated with CAA pathology, suggesting a role for tTG in ECM modulation in CAA. Therefore, inhibition of tTG activity might be a promising novel therapeutic target to counteract CAA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transglutaminases
/
Peptídeos beta-Amiloides
/
Angiopatia Amiloide Cerebral
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article