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"Reported, but still unknown." A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles.
Gerus, Igor I; Mironetz, Roman X; Kondratov, Ivan S; Bezdudny, Andrei V; Dmytriv, Yurii V; Shishkin, Oleg V; Starova, Viktoriia S; Zaporozhets, Olga A; Tolmachev, Andrey A; Mykhailiuk, Pavel K.
Afiliação
  • Gerus II; Enamine Ltd., Oleksandra Matrosova Street, 23, Kyiv 01103, Ukraine. igerus@hotmail.com
J Org Chem ; 77(1): 47-56, 2012 Jan 06.
Article em En | MEDLINE | ID: mdl-22171748
ABSTRACT
Straightforward practical synthetic approaches to 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles have been developed. The key step of the both syntheses is a transformation of the carboxylic group in a pyrazole core into the trifluoromethyl group by sulfur tetrafluoride. The elaborated synthetic protocols allow gram-scale preparation of the target products. The obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pK(a) values and fluorescence measurements.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis Tipo de estudo: Guideline Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis Tipo de estudo: Guideline Idioma: En Ano de publicação: 2012 Tipo de documento: Article