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[Place of the pathologist in the management of primary bone tumors (osteosarcoma and Ewing's family tumors after neoadjuvant treatment)]. / Rôle du pathologiste dans la prise en charge des tumeurs osseuses primitives malignes : ostéosarcomes et tumeurs de la famille Ewing après traitement néoadjuvant.
Gomez-Brouchet, Anne; Bouvier, Corinne; Decouvelaere, Anne-Valérie; Larousserie, Frédérique; Aubert, Sébastien; Leroy, Xavier; Guinebretière, Jean-Marc; Coulomb, Aurore; Cassagnau, Elisabeth; de Muret, Anne; Audard, Virginie; Marie, Béatrice; de Pinieux, Gonzague.
Afiliação
  • Gomez-Brouchet A; Service de pathologie, département d'anatomie et cytologie pathologiques, Toulouse, France. brouchet.anne@chu-toulouse.fr
Ann Pathol ; 31(6): 455-65, 2011 Dec.
Article em Fr | MEDLINE | ID: mdl-22172118
The survival of osteosarcoma and Ewing family tumours has been improved by the introduction of neoadjuvant chemotherapy. The response to preoperative chemotherapy is evaluated on the microscopic analysis of the surgical resection, by the percentage of tumour necrosis according to the Huvos and Rosen's grading. It remains the only reliable prognostic factor for patients and is used to guide the choice of post-operative chemotherapy. The macroscopic and microscopic management of the surgical resection (cf. supra) is essential and is the subject of a specific protocol. Several studies have been conducted to identify news factors able to predict the response to chemotherapy, the tumour aggressiveness and its ability to develop metastases. Inhibitors of mTOR and/or regulators of the balance RANKL/OPG are promising therapeutics. The study's expression of these new factors could be performed on the biopsy and will offer new therapeutic strategy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Patologia Clínica / Papel do Médico / Sarcoma de Ewing / Neoplasias Ósseas / Osteossarcoma / Quimioterapia Adjuvante / Terapia Neoadjuvante / Antineoplásicos Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans Idioma: Fr Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Patologia Clínica / Papel do Médico / Sarcoma de Ewing / Neoplasias Ósseas / Osteossarcoma / Quimioterapia Adjuvante / Terapia Neoadjuvante / Antineoplásicos Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans Idioma: Fr Ano de publicação: 2011 Tipo de documento: Article