Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.
Bioorg Med Chem
; 20(2): 942-8, 2012 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-22178660
ABSTRACT
The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,79,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma brucei brucei
/
Receptores de N-Metil-D-Aspartato
/
Vírus de DNA
/
Aminas
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article