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Skin carcinoma of the head and neck with perineural invasion.
Balamucki, Christopher J; Mancuso, Anthony A; Amdur, Robert J; Kirwan, Jessica M; Morris, Christopher G; Flowers, Franklin P; Stoer, Charles B; Cognetta, Armand B; Mendenhall, William M.
Afiliação
  • Balamucki CJ; Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, USA.
Am J Otolaryngol ; 33(4): 447-54, 2012.
Article em En | MEDLINE | ID: mdl-22185685
PURPOSE: The aim of the study was to update the experience treating cutaneous squamous cell and basal cell carcinomas of the head and neck with incidental or clinical perineural invasion (PNI) with radiotherapy (RT). MATERIALS AND METHODS: From 1965 to 2007, 216 patients received RT alone or with surgery and/or chemotherapy. RESULTS: The 5-year overall, cause-specific, and disease-free survivals for incidental and clinical PNIs were 55% vs 54%, 73% vs 64%, and 67% vs 51%. The 5-year local control, local-regional control, and freedom from distant metastases for incidental and clinical PNIs were 80% vs 54%, 70% vs 51%, and 90% vs 94%. On univariate and multivariate (P = .0038 and .0047) analyses, clinical PNI was a poor prognostic factor for local control. The rates of grade 3 or higher complication in the incidental and clinical PNI groups were 16% and 36%, respectively. CONCLUSIONS: Radiotherapy plays a critical role in the treatment of this disease. Clinical PNI should be adequately irradiated to include the involved nerves to the skull base.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Periférico / Neoplasias Cutâneas / Carcinoma Basocelular / Carcinoma de Células Escamosas Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Periférico / Neoplasias Cutâneas / Carcinoma Basocelular / Carcinoma de Células Escamosas Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article