Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
Biochim Biophys Acta
; 1821(8): 1096-103, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22226883
ABSTRACT
Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine-threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Ceramidas
/
Proteínas Serina-Treonina Quinases
/
Vesículas Transportadoras
/
Retículo Endoplasmático
/
Complexo de Golgi
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article