A new and convenient approach for the preparation of ß-cyanoethyl protected trinucleotide phosphoramidites.
Org Biomol Chem
; 10(8): 1510-3, 2012 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-22231393
ABSTRACT
Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear ß-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Compostos Organofosforados
/
Cianatos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article