Functional interferon system is required for clearance of lassa virus.

Yun, Nadezhda E; Poussard, Allison L; Seregin, Alexey V; Walker, Aida G; Smith, Jennifer K; Aronson, Judith F; Smith, Jeanon N; Soong, Lynn; Paessler, Slobodan

Yun, Nadezhda E; Poussard, Allison L; Seregin, Alexey V; Walker, Aida G; Smith, Jennifer K; Aronson, Judith F; Smith, Jeanon N; Soong, Lynn; Paessler, Slobodan.

Afiliação

Yun NE; Galveston National Laboratory, Institute for Human Infectious and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. neyun@utmb.edu

J Virol ; 86(6): 3389-92, 2012 Mar.

Article em En | MEDLINE | ID: mdl-22238311

RESUMO

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.

Assuntos

Interferons/imunologia; Febre Lassa/imunologia; Vírus Lassa/imunologia; Animais; Feminino; Humanos; Febre Lassa/virologia; Vírus Lassa/fisiologia; Masculino; Camundongos; Camundongos Knockout; Receptores de Interferon/genética; Receptores de Interferon/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Febre Lassa / Vírus Lassa Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article

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