Inhibition of transforming growth factor beta-1 augments liver regeneration after partial portal vein ligation in a porcine experimental model.
Hepatogastroenterology
; 59(113): 235-40, 2012.
Article
em En
| MEDLINE
| ID: mdl-22251543
ABSTRACT
BACKGROUND/AIMS:
TGF-ß1 is a pleiotropic cytokine that is over expressed in terminal phase of liver regeneration.METHODOLOGY:
Twenty-four hours after partial portal vein ligation monoclonal antibody against TGF-ß1 (TGF-ß1 group, 7 piglets) or physiological solution (control group, 9 piglets) were applied into the central venous catheter. The biochemical parameters (bilirubin, urea, creatinine, alkaline phosphatase, gamma- glutamyl transferase, cholinesterase, aspartate aminotransferase, alanine aminotransferase and albumin) were assessed. The compensatory hypertrophy of the non-occluded liver lobes was evaluated by periodic ultrasonography during the next fourteen days and by histological examination.RESULTS:
The acceleration of growth of the hypertrophic liver lobes was maximal between 3rd and 7th postoperative days in comparison with the control group (p<0.05). No important differences in the biochemical or studied histological parameters were proved.CONCLUSIONS:
The present study describes a new usage of monoclonal antibody against TGF-ß1 in large animal experimental model of partial portal vein ligation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Proliferação de Células
/
Fator de Crescimento Transformador beta1
/
Fígado
/
Regeneração Hepática
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article