Prevalence and incidence of microscopic colitis in patients with diarrhoea of unknown aetiology in a region in central Spain.
Dig Liver Dis
; 44(5): 384-8, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22265684
ABSTRACT
BACKGROUND:
Often previously overlooked, microscopic colitis, including collagenous colitis and lymphocytic colitis, has now emerged as a common cause of chronic diarrhoea.AIMS:
To evaluate the prevalence and incidence of microscopic colitis in patients with diarrhoea of unknown aetiology.METHODS:
271 consecutive patients who were referred to the General Hospital of Tomelloso from April 2008 to December 2010 for diarrhoea of unknown aetiology underwent a full colonoscopy to obtain biopsy samples to diagnose microscopic colitis on the basis of commonly accepted histological criteria. All patients were classified according to the Roma III criteria for diarrhoea-dominant irritable bowel syndrome.RESULTS:
In 234/271 consecutive patients with normal endoscopic appearance we observed 32/234 patients with microscopic colitis (30 lymphocytic colitis and 2 collagenous colitis) with a prevalence of microscopic colitis of 48 cases/100,000 inhabitants (95%CI 30-65) and mean annual standardised incidence of 18 cases/100,000 inhabitants (95%CI 16.0-20.0). Analysing only the patients that met the Roma III criteria (84/271), we observed 10.7% microscopic colitis diagnosis, with higher risk in the presence of autoimmune disease, seronegative celiac disease and intake of non-steroidal anti-inflammatory drugs.CONCLUSIONS:
Microscopic colitis was found in 13.7% of patients with chronic diarrhoea. Microscopic colitis is present in a relevant proportion of symptomatic patients meeting diagnostic criteria for irritable bowel syndrome (10.7%).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colite Microscópica
/
Diarreia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Prevalence_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article