Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins.
Bioorg Med Chem
; 20(4): 1468-74, 2012 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-22277590
ABSTRACT
Compounds which inhibit the HIV-1 replication cycle have been found amongst fragment peptides derived from an HIV-1 matrix (MA) protein. Overlapping peptide libraries covering the whole sequence of MA were designed and constructed with the addition of an octa-arginyl group to increase their cell membrane permeability. Imaging experiments with fluorescent-labeled peptides demonstrated these peptides with an octa-arginyl group can penetrate cell membranes. The fusion of an octa-arginyl group was proven to be an efficient way to find active peptides in cells such as HIV-inhibitory peptides.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
HIV
/
Biblioteca de Peptídeos
/
Fármacos Anti-HIV
/
Peptídeos Penetradores de Células
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article