Persistence of alkylated DNA bases in the Mongolian gerbil (Meriones unguiculatus) following a single dose of methylnitrosourea +.
Carcinogenesis
; 1(1): 111-3, 1980 Jan.
Article
em En
| MEDLINE
| ID: mdl-22282988
ABSTRACT
Methylated purines were determined in DNA of various gerbil tissues following a single i.v. injection of N-[14C]methyl-N-nitrosourea (10 mg/kg). Enzymic removal of the promutagenic base O6-methylguanine was most efficient in the liver, followed by kidney, lung and brain. In cerebral DNA, 40% of the initial concentration was still present after 6 months. Since the gerbil brain is apparently not susceptible to the oncogenic effect of methylnitrosourea and related carcinogens, these data indicate that the formation and persistence of O6-alkylguanine may constitute a necessary although not sufficient event for the initiation of organ-specific carcinogenesis by monofunctional alkylating agents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Alquilantes
/
Guanina
/
Metilnitrosoureia
Limite:
Animals
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article