Effects of static and temporally fluctuating tensions on semiflexible polymer looping.
J Chem Phys
; 136(4): 045101, 2012 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-22299917
ABSTRACT
Biopolymer looping is a dynamic process that occurs ubiquitously in cells for gene regulation, protein folding, etc. In cellular environments, biopolymers are often subject to tensions which are either static or temporally fluctuating far away from equilibrium. We study the dynamics of semiflexible polymer looping in the presence of such tensions by using Brownian dynamics simulation combined with an analytical theory. We show a minute tension dramatically changes the looping time, especially for long chains. Considering a dichotomically flipping noise as a simple example of the nonequilibrium tension, we find the phenomenon of resonant activation, where the looping time can be the minimum at an optimal flipping time. We discuss our results in connection with recent experiments.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biopolímeros
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article