GPCR mediated regulation of synaptic transmission.
Prog Neurobiol
; 96(3): 304-21, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22307060
ABSTRACT
Synaptic transmission is a finely regulated mechanism of neuronal communication. The release of neurotransmitter at the synapse is not only the reflection of membrane depolarization events, but rather, is the summation of interactions between ion channels, G protein coupled receptors, second messengers, and the exocytotic machinery itself which exposes the components within a synaptic vesicle to the synaptic cleft. The focus of this review is to explore the role of G protein signaling as it relates to neurotransmission, as well as to discuss the recently determined inhibitory mechanism of Gßγ dimers acting directly on the exocytotic machinery proteins to inhibit neurotransmitter release.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membranas Sinápticas
/
Transmissão Sináptica
/
Receptores Acoplados a Proteínas G
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article