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Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity.
Leung, T F; Chan, P K S; Wong, W K G; Ip, M; Cheng, W T F; Ng, P C.
Afiliação
  • Leung TF; Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital.
Hong Kong Med J ; 18 Suppl 2: 27-30, 2012 Feb.
Article em En | MEDLINE | ID: mdl-22311358
1. Human coronaviruses (HCoVs)were detected in 2.5% of 2982 local children hospitalised for acute respiratory infections in 2005 to 2007. 2. Using the 'pancoronavirus' reverse transcription-polymerase chain reaction assay, detection rates were 0.6% for HCoVNL63,1.2% for HCoV-OC43,0.5% for HCoV-HKU1, and 0.2% for HCoV-229E. Notably, HCoV-NL63 infections were significantly more common among children hospitalised in 2006/2007 (1.2%) than in 2005/2006 (0.3%).3. The peak season for HCoVNL63 infection was autumn(September to October). 4. HCoV-NL63 infection was associated with younger age,croup, febrile convulsion, and acute gastroenteritis. Such disease associations were not found with the other three HCoVs. 5. Most local HCoV-NL63 isolates were closely related to the prototype strain in Netherlands(NL496), but a few were phylogenetically distinct from the major cluster.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Genes pol / Infecções por Coronavirus / Coronavirus Humano NL63 Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2012 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Genes pol / Infecções por Coronavirus / Coronavirus Humano NL63 Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2012 Tipo de documento: Article