Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.
Can Respir J
; 19(1): e1-2, 2012.
Article
em En
| MEDLINE
| ID: mdl-22332138
Endothelin receptor antagonists are commonly used in the treatment of pulmonary hypertension. Sitaxsentan, a selective endothelin A receptor blocker, induces a mild transaminitis in approximately 3% to 5% of patients, but rarely an acute severe hepatitis. A case involving a 61-year-old female with sitaxsentan-induced acute severe liver failure is presented. Depite withdrawal of therapy, her liver tests failed to improve. After six weeks of monitoring, the patient was administered high-dose corticosteroids, with a good clinical and biochemical response. While endothelin receptor antagonists are postulated to cause hepatitis by inhibition of a bile salt transporter pump, an immune-mediated or idiosyncratic mechanism should be considered.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Falência Hepática Aguda
/
Doença Hepática Induzida por Substâncias e Drogas
/
Antagonistas dos Receptores de Endotelina
/
Glucocorticoides
/
Isoxazóis
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article