"Virtual" lesioning of the human oropharyngeal motor cortex: a videofluoroscopic study.
Arch Phys Med Rehabil
; 93(11): 1987-90, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22336105
ABSTRACT
OBJECTIVE:
To use focal cortical inhibition and create a "virtual" lesion in the oropharyngeal motor cortex in healthy subjects to determine whether this provokes swallowing dysfunction.DESIGN:
Intervention study before and after cortical stimulation.SETTING:
Tertiary care center.PARTICIPANTS:
Healthy adult volunteers (N=9; age range, 21-44y) participated in the study.INTERVENTIONS:
Active or sham 1-Hz repetitive transcranial magnetic stimulation (rTMS) over the cortical sites in each hemisphere evoking the largest mylohyoid motor-evoked potentials (mMEPs) to single pulse transcranial magnetic stimulation. MAIN OUTCOMEMEASURES:
Videofluoroscopic assessment was performed before and 5, 30, and 60 minutes after rTMS.RESULTS:
The motor threshold was 83%±10% for the hemisphere with the larger mMEP (dominant) and 92%±9% for the hemisphere with the smaller mMEP (nondominant). When rTMS was performed over the dominant hemisphere, there was a decrease in oral transit time (P=.05), an increase in swallow reaction time (P=.0001), but no change of pharyngeal transit time or laryngeal closure duration. When rTMS was performed on the nondominant hemisphere, there was also a decrease in oral transit time (P=.05), but no change in any of the other swallowing measures. Neither active intervention produced any signs of aspiration or penetration. Sham stimulation had no effect.CONCLUSIONS:
Inhibiting the human oropharyngeal motor cortex using rTMS transiently modifies swallowing behavior in a way reminiscent to that seen in stroke patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Deglutição
/
Modalidades de Fisioterapia
/
Acidente Vascular Cerebral
/
Estimulação Magnética Transcraniana
/
Modelos Biológicos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article