Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.
Bioorg Med Chem Lett
; 22(6): 2212-5, 2012 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-22342631
The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pirimidinas
/
RNA Viral
/
Hepacivirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article