Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage.
J Immunol
; 188(7): 3208-16, 2012 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-22351937
ABSTRACT
The earliest thymic progenitors (ETPs) were recently shown to give rise to both lymphoid and myeloid cells. Whereas the majority of ETPs are derived from IL-7Rα-positive cells and give rise exclusively to T cells, the origin of the myeloid cells remains undefined. In this study, we show both in vitro and in vivo that IL-13Rα1(+) ETPs yield myeloid cells with no potential for maturation into T cells, whereas IL-13Rα1(-) ETPs lack myeloid potential. Moreover, transfer of lineage-negative IL-13Rα1(+) bone marrow stem cells into IL-13Rα1-deficient mice reconstituted thymic IL-13Rα1(+) myeloid ETPs. Myeloid cells or macrophages in the thymus are regarded as phagocytic cells whose function is to clear apoptotic debris generated during T cell development. However, the myeloid cells derived from IL-13Rα1(+) ETPs were found to perform Ag-presenting functions. Thus, IL-13Rα1 defines a new class of myeloid restricted ETPs yielding APCs that could contribute to development of T cells and the control of immunity and autoimmunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
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Células da Medula Óssea
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Antígenos de Diferenciação
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Mielopoese
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Subunidade alfa1 de Receptor de Interleucina-13
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Células Progenitoras de Granulócitos e Macrófagos
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Células Apresentadoras de Antígenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article