Chemical synthesis of the cardiotonic steroid glycosides and related natural products.
Chemistry
; 18(11): 3092-120, 2012 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-22354477
The active components from the extracts of Digitalis, cardiotonic steroid glycosides, have been ingested by humans for more than 200 years as a medicinal therapy for heart failure and abnormal heart rhythms. The positive inotropic activity of the cardiotonic steroids that mediates clinically useful physiological effects in patients has been attributed largely to a high affinity inhibitory interaction with the extracellular surface of the membrane-bound sodium pump (Na(+)/K(+)-ATPase). However, previously unrecognized intracellular signaling pathways continue to be uncovered. This Review examines both partial and de novo synthetic approaches to the medicinally important and structurally captivating cardenolide and bufadienolide steroid families, with an emphasis on the stereocontrolled construction of the pharmacophoric aglycone (genin) framework.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Glicosídeos Cardíacos
/
Glicosídeos Digitálicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article