Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
J Cell Sci
; 125(Pt 10): 2446-56, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22357953
ABSTRACT
Wnt signaling is initiated upon binding of Wnt proteins to Frizzled proteins and their co-receptors LRP5 and 6. The signal is then propagated to several downstream effectors, mediated by the phosphoprotein scaffold, dishevelled. We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation. G3BP2, a dishevelled-associated protein, is methylated in response to Wnt3a. The Wnt3a-induced LRP6 phosphorylation is attenuated by G3BP2 knockdown, chemical inhibition of methyl transferase activity or expression of methylation-deficient mutants of G3BP2. Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive 'switch' regulating LRP6 phosphorylation and canonical Wnt-ß-catenin signaling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
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Proteínas de Transporte
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Proteínas Ativadoras de ras GTPase
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Proteína Wnt3A
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Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article