[Early onset of anti- erythropoietin antibody-mediated pure red cell aplasia after commencement of subcutaneous administration of epoetin-ß].
Rinsho Ketsueki
; 53(1): 110-2, 2012 Jan.
Article
em Ja
| MEDLINE
| ID: mdl-22374534
ABSTRACT
We report a 73-year-old Japanese man with early onset pure red cell aplasia (PRCA) caused by subcutaneous administration of recombinant epoetin-ß. Two months after the start of epoetin therapy, he developed PRCA. Anti-erythropoietin (EPO) antibody, detected in the patient's serum by enzyme immunoassay and radioimmunoprecipitation method, inhibited EPO-dependent growth of AS-E2 cells in vitro. Treatment with prednisone (1 mg/kg) significantly reduced antibody levels 3 months later. It is important to have an awareness of antibody-mediated PRCA. Our case shows that subcutaneous epoetin administration produces this complication in the early period of therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eritropoetina
/
Aplasia Pura de Série Vermelha
/
Anticorpos
Limite:
Aged
/
Humans
/
Male
Idioma:
Ja
Ano de publicação:
2012
Tipo de documento:
Article