[Preclinical imaging in animal models of radiation therapy]. / Präklinische Bildgebung im Tiermodell bei Strahlentherapie.
Radiologe
; 52(3): 252-62, 2012 Mar.
Article
em De
| MEDLINE
| ID: mdl-22382437
ABSTRACT
CLINICAL/METHODICAL ISSUE Modern radiotherapy benefits from precise and targeted diagnostic and pretherapeutic imaging. STANDARD RADIOLOGICAL METHODS:
Standard imaging modalities, such as computed tomography (CT) offer high morphological detail but only limited functional information on tumors. METHODICAL INNOVATIONS Novel functional and molecular imaging modalities provide biological information about tumors in addition to detailed morphological information. PERFORMANCE Perfusion magnetic resonance imaging (MRI) CT or ultrasound-based perfusion imaging as well as hybrid modalities, such as positron emission tomography (PET) CT or MRI-PET have the potential to identify and precisely delineate viable and/or perfused tumor areas, enabling optimization of targeted radiotherapy. Functional information on tissue microcirculation and/or glucose metabolism allow a more precise definition and treatment of tumors while reducing the radiation dose and sparing the surrounding healthy tissue. ACHIEVEMENTS In the development of new imaging methods for planning individualized radiotherapy, preclinical imaging and research plays a pivotal role, as the value of multimodality imaging can only be assessed, tested and adequately developed in a preclinical setting, i.e. in animal tumor models. PRACTICALRECOMMENDATIONS:
New functional imaging modalities will play an increasing role for the surveillance of early treatment response during radiation therapy and in the assessment of the potential value of new combination therapies (e.g. combining anti-angiogenic drugs with radiotherapy).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico por Imagem
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Modelos Animais de Doenças
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Radioterapia Guiada por Imagem
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Neoplasias
Tipo de estudo:
Diagnostic_studies
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Guideline
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Prognostic_studies
Limite:
Animals
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Humans
Idioma:
De
Ano de publicação:
2012
Tipo de documento:
Article