Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.
Biochem Med (Zagreb)
; 22(1): 109-13, 2012.
Article
em En
| MEDLINE
| ID: mdl-22384525
INTRODUCTION: The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period. MATERIALS AND METHODS: The serum levels of IL-1beta, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers. RESULTS: Serum IL-1beta levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1beta and CRP (r = 0.513, P = 0.002) values of FMF group. CONCLUSIONS: In conclusion, our results confirm the presence of increased IL-1beta levels in FMF patients during attack-free period. Serum IL-1beta values seems to correlate with CRP levels. The elevation of IL-1beta levels may be important in monitoring subclinical inflammation of attack free period in FMF patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Familiar do Mediterrâneo
/
Proteína C-Reativa
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Proteínas de Fase Aguda
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Reação de Fase Aguda
/
Interleucina-1beta
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article