Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
Bioorg Med Chem Lett
; 22(7): 2424-7, 2012 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-22390834
The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Ácido Ascórbico
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Sequestradores de Radicais Livres
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Espécies Reativas de Oxigênio
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Herpesvirus Humano 1
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article