A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.
Genes Dev
; 26(6): 542-7, 2012 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-22426531
ABSTRACT
The COMA/CENP-H/I kinetochore complex regulates microtubule dynamics at kinetochores. The complex is also required to generate spindle checkpoint signals in both yeast and human cells under conditions where Aurora B activity is compromised. Our data explain why mammalian cells treated with Aurora inhibitors still have a functional spindle assembly checkpoint (SAC), since the checkpoint signals through CENP-H/I/N. The SAC effect from depleting the CENP-H/I/N complex cannot be explained by a weakened SAC signal, and the complex has no role in the SAC response to paclitaxel. We propose a model to explain the differential response of human cells to nocodazole and paclitaxel.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Cromossômicas não Histona
/
Proteínas de Ligação a DNA
/
Pontos de Checagem da Fase M do Ciclo Celular
/
Fuso Acromático
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article