Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure.
Nephron
; 56(2): 157-61, 1990.
Article
em En
| MEDLINE
| ID: mdl-2243570
ABSTRACT
Serum concentrations of soluble interleukin 2 receptor (IL-2R) were measured in 65 hemodialysis patients and compared with serum levels of beta 2-microglobulin and tissue polypeptide antigen (TPA). Elevated IL-2R levels, found in 85% of examined patients, correlated with elevated TPA serum concentrations (p less than 0.05). Patients with high IL-2R levels were significantly younger (p less than 0.05) than patients with low levels. Primary renal disease and residual renal function had no significant influence on TPA or IL-2R serum concentrations. In 16 patients with carpal tunnel syndrome, increased serum concentrations of IL-2R (p less than 0.005) and TPA (p less than 0.001) were found. We conclude that a non-specific dialysis-induced activation of epithelial and lymphoid cells rather than a specific immune response could explain the concomitant elevation of IL-2R and TPA serum concentrations in hemodialyzed patients. Patients with pronounced cell turnover, reflected by elevated IL-2R and TPA levels, may show an increased susceptibility to dialysis-associated amyloidosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Receptores de Interleucina-2
/
Falência Renal Crônica
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article