Interleukin-1 affects the behavioral despair response in rats by an indirect mechanism which requires endogenous CRF.
Brain Res
; 528(1): 162-4, 1990 Sep 24.
Article
em En
| MEDLINE
| ID: mdl-2245334
ABSTRACT
Interleukin-1 (IL-1) administered intracerebroventricularly (i.c.v.) to rats significantly reduces the level of immobility in animals forced to swim in a confined space. Immunoneutralization of endogenous CRF (corticotropin-releasing factor) by i.c.v. administration of CRF-antiserum prevents the IL-1-induced sinking in rats. This shows that the release of cerebral CRF, probably from the hypothalamus, may mediate the behavioral effect promoted by IL-1. Taken together our results suggest the existence of a complex interface between immune, neuroendocrine and behavioral regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Hormônio Liberador da Corticotropina
/
Interleucina-1
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article