Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats.
J Pharmacol Sci
; 118(4): 547-51, 2012.
Article
em En
| MEDLINE
| ID: mdl-22466962
ABSTRACT
Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
/
Amitriptilina
/
Hiperalgesia
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article