Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: enantioselective conjugate cyanation of ß-aryl-ß-trifluoromethyl-disubstituted enones.
Angew Chem Int Ed Engl
; 51(20): 4959-62, 2012 May 14.
Article
em En
| MEDLINE
| ID: mdl-22473774
ABSTRACT
Ether way the cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Hidrocarbonetos Fluorados
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article