Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties: characterization and applications.
J Natl Cancer Inst
; 82(23): 1821-6, 1990 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-2250297
ABSTRACT
Immunogenic, nontumorigenic cell variants derived from the highly tumorigenic mouse lymphoma cell line S-49 were used to raise monoclonal antibodies (MAbs) in syngeneic BALB/c mice. MAbs of the following specifications were derived (a) MAbs that interacted preferentially with the immunogenic variants, (b) MAbs that interacted with both immunogenic variants and parental tumorigenic cells, and (c) a MAb that interacted with both immunogenic and tumorigenic S-49 cells and the normal BALB/c splenocytes. Six MAbs raised in this way were found to recognize at least five different cell-surface epitopes. Functional analysis of the different MAbs suggested their potential usefulness in passive immunization against parental tumorigenic cells as well as in enrichment of immunogenic cells from a mixed population containing a preponderance of tumorigenic cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article