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The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates.
Mario, Débora Alves Nunes; Denardi, Laura Bedin; Bandeira, Laíssa Arévalo; Antunes, Milene Silva; Santurio, Janio Morais; Severo, Luiz Carlos; Alves, Sydney Hartz.
Afiliação
  • Mario DA; Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. debora_alves6@hotmail.com
Mem Inst Oswaldo Cruz ; 107(3): 433-6, 2012 May.
Article em En | MEDLINE | ID: mdl-22510843
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazóis / Fluconazol / Anfotericina B / Candida glabrata / Equinocandinas / Antifúngicos Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazóis / Fluconazol / Anfotericina B / Candida glabrata / Equinocandinas / Antifúngicos Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2012 Tipo de documento: Article