Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts.
Org Biomol Chem
; 10(20): 4109-15, 2012 May 28.
Article
em En
| MEDLINE
| ID: mdl-22517166
ABSTRACT
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Ácidos e Sais Biliares
/
Glicina
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article