Etanercept treatment enhances clinical and neuroelectrophysiological recovery in partial spinal cord injury.
Eur Spine J
; 21(12): 2588-93, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22526707
ABSTRACT
PURPOSE:
To investigate the effect of an anti-TNF-α agent (etanercept) on recovery processes in a partial spinal cord injury (SCI) model using clinical and electrophysiological tests.METHODS:
Twenty-four New Zealand rabbits were divided into three groups group 1 [SCI + 2 ml saline intramuscular (i.m.), n = 8], group 2 (SCI + 2.5 mg/kg etanercept, i.m., 2-4 h after SCI, n = 8) and group 3 (SCI + 2.5 mg/kg etanercept, i.m., 12-24 h after SCI, n = 8). Rabbits were evaluated before SCI, immediately after SCI, 1 week after, and 2 weeks after SCI, clinically by Tarlov scale and electrophysiologically by SEP.RESULTS:
Tarlov scores of groups 2 and 3 were significantly better than group 1, 2 weeks after SCI. SEP recovery was significantly better in groups 2 and 3 than group 1, 2 weeks after SCI.CONCLUSIONS:
These results show that blocking TNF-α mediated inflammation pathway by an anti-TNF-α agent enhances clinical and electrophysiological recovery processes in partial SCI model.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
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Imunoglobulina G
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Receptores do Fator de Necrose Tumoral
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Fármacos Neuroprotetores
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Recuperação de Função Fisiológica
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Potenciais Somatossensoriais Evocados
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article