The FSH-inhibin axis in prader-willi syndrome: heterogeneity of gonadal dysfunction.
Reprod Biol Endocrinol
; 10: 39, 2012 May 06.
Article
em En
| MEDLINE
| ID: mdl-22559970
ABSTRACT
BACKGROUND:
We characterized the spectrum and etiology of hypogonadism in a cohort of Prader-Willi syndrome (PWS) adolescents and adults.METHODS:
Reproductive hormonal profiles and physical examination were performed on 19 males and 16 females ages 16-34 years with PWS. Gonadotropins, sex-steroids, inhibin B (INB) and anti-Mullerian hormone (AMH) were measured. We defined 4 groups according to the relative contribution of central and gonadal dysfunction based on FSH and INB levels Group A primary hypogonadism (FSH >15 IU/l and undetectable INB (<10 pg/ml); Group B central hypogonadism (FSH <0.5 IU/l, INB <10 pg/ml); Group C partial gonadal & central dysfunction (FSH 1.5-15 IU/l, INB >20 pg/ml); Group D mild central and severe gonadal dysfunction (FSH 1.5-15 IU/l, INB < 10 pg/ml.RESULTS:
There were 10, 8, 9 and 8 individuals in Groups A-D respectively; significantly more males in group A (9, 4, 4 and 2; P = 0.04). Significant differences between the groups were found in mean testosterone (P = 0.04), AMH (P = 0.003) and pubic hair (P = 0.04) in males and mean LH (P = 0.003) and breast development (P = 0.04) in females. Mean age, height, weight, BMI and the distribution of genetic subtypes were similar within the groups.CONCLUSIONS:
Analysis of FSH and inhibin B revealed four distinct phenotypes ranging from primary gonadal to central hypogonadism. Primary gonadal dysfunction was common, while severe gonadotropin deficiency was rare. Longitudinal studies are needed to verify whether the individual phenotypes are consistent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Prader-Willi
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Hormônio Foliculoestimulante
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Transtornos Gonadais
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Inibinas
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article